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Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability
Artemis was initially discovered as the gene inactivated in human radiosensitive T(−)B(−) severe combined immunodeficiency, a syndrome characterized by the absence of B and T lymphocytes and cellular hypersensitivity to ionizing radiation. Hypomorphic Artemis alleles have also been identified in pat...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715118/ https://www.ncbi.nlm.nih.gov/pubmed/19349461 http://dx.doi.org/10.1084/jem.20082396 |