Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks

To investigate mtDNA recombination induced by multiple double strand breaks (DSBs) we used a mitochondria-targeted form of the ScaI restriction endonuclease to introduce DSBs in heteroplasmic mice and cells in which we were able to utilize haplotype differences to trace the origin of recombined mole...

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Detalles Bibliográficos
Autores principales: Bacman, Sandra R., Williams, Sion L., Moraes, Carlos T.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715231/
https://www.ncbi.nlm.nih.gov/pubmed/19435881
http://dx.doi.org/10.1093/nar/gkp348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715231/
https://www.ncbi.nlm.nih.gov/pubmed/19435881
http://dx.doi.org/10.1093/nar/gkp348

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