HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy

HMGA proteins are not translated in normal human somatic cells, but are present in high copy numbers in pluripotent embryonic stem cells and most neoplasias. Correlations between the degree of malignancy, patient prognostic index and HMGA levels have been firmly established. Intriguingly, HMGA2 is a...

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Detalles Bibliográficos
Autores principales: Summer, Heike, Li, Ou, Bao, Qiuye, Zhan, Lihong, Peter, Sabrina, Sathiyanathan, Padmapriya, Henderson, Dana, Klonisch, Thomas, Goodman, Steven D., Dröge, Peter
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715238/
https://www.ncbi.nlm.nih.gov/pubmed/19465398
http://dx.doi.org/10.1093/nar/gkp375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715238/
https://www.ncbi.nlm.nih.gov/pubmed/19465398
http://dx.doi.org/10.1093/nar/gkp375

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