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A conformational change in the helicase core is necessary but not sufficient for RNA unwinding by the DEAD box helicase YxiN
Cooperative binding of ATP and RNA to DEAD-box helicases induces the closed conformation of their helicase core, with extensive interactions across the domain interface. The bound RNA is bent, and its distortion may constitute the first step towards RNA unwinding. To dissect the role of the conforma...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715247/ https://www.ncbi.nlm.nih.gov/pubmed/19474341 http://dx.doi.org/10.1093/nar/gkp397 |