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Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting
Nucleoside analogs (NAs) represent an important category of prodrugs for the treatment of viral infections and cancer, yet the biological potency of many analogs is compromised by their inefficient activation through cellular 2′-deoxyribonucleoside kinases (dNKs). We herein report the directed evolu...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715250/ https://www.ncbi.nlm.nih.gov/pubmed/19474348 http://dx.doi.org/10.1093/nar/gkp400 |