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High-affinity triplex targeting of double stranded DNA using chemically modified peptide nucleic acid oligomers
While sequence-selective dsDNA targeting by triplex forming oligonucleotides has been studied extensively, only very little is known about the properties of PNA–dsDNA triplexes—mainly due to the competing invasion process. Here we show that when appropriately modified using pseudoisocytosine substit...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715256/ https://www.ncbi.nlm.nih.gov/pubmed/19474349 http://dx.doi.org/10.1093/nar/gkp437 |