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High-affinity triplex targeting of double stranded DNA using chemically modified peptide nucleic acid oligomers

While sequence-selective dsDNA targeting by triplex forming oligonucleotides has been studied extensively, only very little is known about the properties of PNA–dsDNA triplexes—mainly due to the competing invasion process. Here we show that when appropriately modified using pseudoisocytosine substit...

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Detalles Bibliográficos
Autores principales:	Hansen, Mads E., Bentin, Thomas, Nielsen, Peter E.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Chemistry and Synthetic Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715256/ https://www.ncbi.nlm.nih.gov/pubmed/19474349 http://dx.doi.org/10.1093/nar/gkp437

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