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Design effect in multicenter studies: gain or loss of power?
BACKGROUND: In a multicenter trial, responses for subjects belonging to a common center are correlated. Such a clustering is usually assessed through the design effect, defined as a ratio of two variances. The aim of this work was to describe and understand situations where the design effect involve...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715424/ https://www.ncbi.nlm.nih.gov/pubmed/19538744 http://dx.doi.org/10.1186/1471-2288-9-39 |