Tolerance Induction to Cytoplasmic β-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity

BACKGROUND: Hepatic gene transfer, in particular using adeno-associated viral (AAV) vectors, has been shown to induce immune tolerance to several protein antigens. This approach has been exploited in animal models of inherited protein deficiency for systemic delivery of therapeutic proteins. Adequat...

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Detalles Bibliográficos
Autores principales: Martino, Ashley T., Nayak, Sushrusha, Hoffman, Brad E., Cooper, Mario, Liao, Gongxian, Markusic, David M., Byrne, Barry J., Terhorst, Cox, Herzog, Roland W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715858/
https://www.ncbi.nlm.nih.gov/pubmed/19652717
http://dx.doi.org/10.1371/journal.pone.0006376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715858/
https://www.ncbi.nlm.nih.gov/pubmed/19652717
http://dx.doi.org/10.1371/journal.pone.0006376

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