Accelerated Immunodeficiency by Anti-CCR5 Treatment in HIV Infection

In 50% of progressing HIV-1 patients, CXCR4-tropic (X4) virus emerges late in infection, often overtaking CCR5-tropic (R5) virus as the dominant viral strain. This “phenotypic switch” is strongly associated with rapidly declining CD4(+) T cell counts and AIDS onset, yet its causes remain unknown. He...

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Detalles Bibliográficos
Autores principales: Weinberger, Ariel D., Perelson, Alan S., Ribeiro, Ruy M., Weinberger, Leor S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715863/
https://www.ncbi.nlm.nih.gov/pubmed/19680436
http://dx.doi.org/10.1371/journal.pcbi.1000467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715863/
https://www.ncbi.nlm.nih.gov/pubmed/19680436
http://dx.doi.org/10.1371/journal.pcbi.1000467

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