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Accelerated Immunodeficiency by Anti-CCR5 Treatment in HIV Infection
In 50% of progressing HIV-1 patients, CXCR4-tropic (X4) virus emerges late in infection, often overtaking CCR5-tropic (R5) virus as the dominant viral strain. This “phenotypic switch” is strongly associated with rapidly declining CD4(+) T cell counts and AIDS onset, yet its causes remain unknown. He...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715863/ https://www.ncbi.nlm.nih.gov/pubmed/19680436 http://dx.doi.org/10.1371/journal.pcbi.1000467 |