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Large-scale chemical dissection of mitochondrial function
Mitochondrial oxidative phosphorylation (OXPHOS) is central to physiology and disease pathogenesis. To systematically investigate its activity and regulation, we performed a wide range of assays of OXPHOS physiology and nuclear and mitochondrial gene expression across 2490 chemical perturbations in...
Autores principales: | Wagner, Bridget K., Kitami, Toshimori, Gilbert, Tamara J., Peck, David, Ramanathan, Arvind, Schreiber, Stuart L., Golub, Todd R., Mootha, Vamsi K. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715872/ https://www.ncbi.nlm.nih.gov/pubmed/18297058 http://dx.doi.org/10.1038/nbt1387 |
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