Single-Molecule Imaging of an in Vitro-Evolved RNA Aptamer Reveals Homogeneous Ligand Binding Kinetics

[Image: see text] Many studies of RNA folding and catalysis have revealed conformational heterogeneity, metastable folding intermediates, and long-lived states with distinct catalytic activities. We have developed a single-molecule imaging approach for investigating the functional heterogeneity of i...

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Detalles Bibliográficos
Autores principales: Elenko, Mark P., Szostak, Jack W., van Oijen, Antoine M.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716146/
https://www.ncbi.nlm.nih.gov/pubmed/19572753
http://dx.doi.org/10.1021/ja901880v

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716146/
https://www.ncbi.nlm.nih.gov/pubmed/19572753
http://dx.doi.org/10.1021/ja901880v

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