WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth

INTRODUCTION: In breast cancer, deregulation of the WNT signaling pathway occurs by autocrine mechanisms. WNT ligands and Frizzled receptors are coexpressed in primary breast tumors and cancer cell lines. Moreover, many breast tumors show hypermethylation of the secreted Frizzled-related protein 1 (...

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Detalles Bibliográficos
Autores principales: Matsuda, Yutaka, Schlange, Thomas, Oakeley, Edward J, Boulay, Anne, Hynes, Nancy E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716500/
https://www.ncbi.nlm.nih.gov/pubmed/19473496
http://dx.doi.org/10.1186/bcr2317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716500/
https://www.ncbi.nlm.nih.gov/pubmed/19473496
http://dx.doi.org/10.1186/bcr2317

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