Frequent Missense and Insertion/Deletion Polymorphisms in the Ovine Shadoo Gene Parallel Species-Specific Variation in PrP

BACKGROUND: The cellular prion protein PrP(C) is encoded by the Prnp gene. This protein is expressed in the central nervous system (CNS) and serves as a precursor to the misfolded PrP(Sc) isoform in prion diseases. The prototype prion disease is scrapie in sheep, and whereas Prnp exhibits common mis...

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Detalles Bibliográficos
Autores principales: Daude, Nathalie, Wohlgemuth, Serene, Rogaeva, Ekaterina, Farid, A. Hossein, Heaton, Mike, Westaway, David
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716538/
https://www.ncbi.nlm.nih.gov/pubmed/19657386
http://dx.doi.org/10.1371/journal.pone.0006538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716538/
https://www.ncbi.nlm.nih.gov/pubmed/19657386
http://dx.doi.org/10.1371/journal.pone.0006538

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