Apoptosis of CD4(+)CD25(high) T Cells in Type 1 Diabetes May Be Partially Mediated by IL-2 Deprivation

BACKGROUND: Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease targeting the insulin-producing pancreatic β cells. Naturally occurring FOXP3(+)CD4(+)CD25(high) regulatory T cells (T(regs)) play an important role in dominant tolerance, suppressing autoreactive CD4(+) effector T cell activi...

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Detalles Bibliográficos
Autores principales: Jailwala, Parthav, Waukau, Jill, Glisic, Sanja, Jana, Srikanta, Ehlenbach, Sarah, Hessner, Martin, Alemzadeh, Ramin, Matsuyama, Shigemi, Laud, Purushottam, Wang, Xujing, Ghosh, Soumitra
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716541/
https://www.ncbi.nlm.nih.gov/pubmed/19654878
http://dx.doi.org/10.1371/journal.pone.0006527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716541/
https://www.ncbi.nlm.nih.gov/pubmed/19654878
http://dx.doi.org/10.1371/journal.pone.0006527

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