The WAVE Regulatory Complex is Inhibited

The WAVE Regulatory Complex (WRC) transmits information from the Rac GTPase to the actin nucleator, Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex, but can be activated by Rac in nucleotide dependent...

Descripción completa

Detalles Bibliográficos
Autores principales: Ismail, Ayman M., Padrick, Shae B., Chen, Baoyu, Umetani, Junko, Rosen, Michael K.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716658/
https://www.ncbi.nlm.nih.gov/pubmed/19363480
http://dx.doi.org/10.1038/nsmb.1587
Descripción
Sumario:The WAVE Regulatory Complex (WRC) transmits information from the Rac GTPase to the actin nucleator, Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex, but can be activated by Rac in nucleotide dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family.

Ejemplares similares