The WAVE Regulatory Complex is Inhibited

The WAVE Regulatory Complex (WRC) transmits information from the Rac GTPase to the actin nucleator, Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex, but can be activated by Rac in nucleotide dependent...

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Autores principales: Ismail, Ayman M., Padrick, Shae B., Chen, Baoyu, Umetani, Junko, Rosen, Michael K.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716658/
https://www.ncbi.nlm.nih.gov/pubmed/19363480
http://dx.doi.org/10.1038/nsmb.1587
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author Ismail, Ayman M.
Padrick, Shae B.
Chen, Baoyu
Umetani, Junko
Rosen, Michael K.
author_facet Ismail, Ayman M.
Padrick, Shae B.
Chen, Baoyu
Umetani, Junko
Rosen, Michael K.
author_sort Ismail, Ayman M.
collection PubMed
description The WAVE Regulatory Complex (WRC) transmits information from the Rac GTPase to the actin nucleator, Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex, but can be activated by Rac in nucleotide dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family.
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spelling pubmed-27166582009-11-01 The WAVE Regulatory Complex is Inhibited Ismail, Ayman M. Padrick, Shae B. Chen, Baoyu Umetani, Junko Rosen, Michael K. Nat Struct Mol Biol Article The WAVE Regulatory Complex (WRC) transmits information from the Rac GTPase to the actin nucleator, Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex, but can be activated by Rac in nucleotide dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family. 2009-04-12 2009-05 /pmc/articles/PMC2716658/ /pubmed/19363480 http://dx.doi.org/10.1038/nsmb.1587 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ismail, Ayman M.
Padrick, Shae B.
Chen, Baoyu
Umetani, Junko
Rosen, Michael K.
The WAVE Regulatory Complex is Inhibited
title The WAVE Regulatory Complex is Inhibited
title_full The WAVE Regulatory Complex is Inhibited
title_fullStr The WAVE Regulatory Complex is Inhibited
title_full_unstemmed The WAVE Regulatory Complex is Inhibited
title_short The WAVE Regulatory Complex is Inhibited
title_sort wave regulatory complex is inhibited
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716658/
https://www.ncbi.nlm.nih.gov/pubmed/19363480
http://dx.doi.org/10.1038/nsmb.1587
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