Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy

BACKGROUND: The Toll-like receptors (TLRs) mediate innate immunity to various pathogens. A mutation (S180L) in the TLR downstream signal transducer TIRAP has recently been reported to be common in Europeans and Africans and to roughly half the risks of heterogeneous infectious diseases including mal...

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Detalles Bibliográficos
Autores principales: Hamann, Lutz, Kumpf, Oliver, Schuring, Ron P, Alpsoy, Erkan, Bedu-Addo, George, Bienzle, Ulrich, Oskam, Linda, Mockenhaupt, Frank P, Schumann, Ralf R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717080/
https://www.ncbi.nlm.nih.gov/pubmed/19602285
http://dx.doi.org/10.1186/1471-2350-10-65

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717080/
https://www.ncbi.nlm.nih.gov/pubmed/19602285
http://dx.doi.org/10.1186/1471-2350-10-65

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