A Discrete Alcohol Pocket Involved in GIRK Channel Activation

Ethanol modifies neural activity in the brain by modulating ion channels. Ethanol activates G protein-gated inwardly rectifying K(+) channels, but the molecular mechanism is not well understood. Here, we used a crystal structure of a mouse inward rectifier containing a bound alcohol and structure-ba...

Descripción completa

Detalles Bibliográficos
Autores principales: Aryal, Prafulla, Dvir, Hay, Choe, Senyon, Slesinger, Paul A.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717173/
https://www.ncbi.nlm.nih.gov/pubmed/19561601
http://dx.doi.org/10.1038/nn.2358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717173/
https://www.ncbi.nlm.nih.gov/pubmed/19561601
http://dx.doi.org/10.1038/nn.2358

Ejemplares similares