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A Discrete Alcohol Pocket Involved in GIRK Channel Activation

Ethanol modifies neural activity in the brain by modulating ion channels. Ethanol activates G protein-gated inwardly rectifying K(+) channels, but the molecular mechanism is not well understood. Here, we used a crystal structure of a mouse inward rectifier containing a bound alcohol and structure-ba...

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Detalles Bibliográficos
Autores principales:	Aryal, Prafulla, Dvir, Hay, Choe, Senyon, Slesinger, Paul A.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717173/ https://www.ncbi.nlm.nih.gov/pubmed/19561601 http://dx.doi.org/10.1038/nn.2358

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