Carbonate and carbamate derivatives of 4-demethylpenclomedine as novel anticancer agents

PURPOSE: The purpose of this investigation was to synthesize a series of carbonate and carbamate derivatives of 4-demethylpenclomedine (DM-PEN), the major plasma non-toxic metabolite of penclomedine (PEN) seen in patients. DM-PEN has been observed to be an active antitumor agent in mouse human xenog...

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Detalles Bibliográficos
Autores principales: Morgan, Lee Roy, Struck, Robert F., Waud, William R., LeBlanc, Blaise, Rodgers, Andrew H., Jursic, Branko S.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717391/
https://www.ncbi.nlm.nih.gov/pubmed/19255760
http://dx.doi.org/10.1007/s00280-009-0933-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717391/
https://www.ncbi.nlm.nih.gov/pubmed/19255760
http://dx.doi.org/10.1007/s00280-009-0933-9

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