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Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape
We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, suc...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717928/ https://www.ncbi.nlm.nih.gov/pubmed/19607682 http://dx.doi.org/10.1186/1745-6150-4-22 |