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Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution

BACKGROUND: HIV-1 integrase (IN) is an attractive target for the development of drugs to treat AIDS, and inhibitors of this viral enzyme are already in the clinic. Nevertheless, there is a continuing need to devise new approaches to block the activity of this viral protein because of the emergence o...

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Detalles Bibliográficos
Autores principales: Andrake, Mark D, Ramcharan, Joseph, Merkel, George, Zhao, Xue Zhi, Burke, Terrence R, Skalka, Anna Marie
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717984/
https://www.ncbi.nlm.nih.gov/pubmed/19563676
http://dx.doi.org/10.1186/1742-6405-6-14