State-Dependent Accessibility of the P-S6 Linker of Pacemaker (HCN) Channels Supports a Dynamic Pore-to-Gate Coupling Model

The hyperpolarization-activated cyclic nucleotide-modulated channel gene family (HCN1-4) encodes the membrane depolarizing current that underlies pacemaking. Although the topology of HCN resembles K(v) channels, much less is known about their structure-function correlation. Previously, we identified...

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Detalles Bibliográficos
Autores principales: Siu, Chung Wah, Azene, Ezana M., Au, Ka Wing, Lau, Chu Pak, Tse, Hung Fat, Li, Ronald A.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718208/
https://www.ncbi.nlm.nih.gov/pubmed/19609824
http://dx.doi.org/10.1007/s00232-009-9184-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718208/
https://www.ncbi.nlm.nih.gov/pubmed/19609824
http://dx.doi.org/10.1007/s00232-009-9184-2

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