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State-Dependent Accessibility of the P-S6 Linker of Pacemaker (HCN) Channels Supports a Dynamic Pore-to-Gate Coupling Model

The hyperpolarization-activated cyclic nucleotide-modulated channel gene family (HCN1-4) encodes the membrane depolarizing current that underlies pacemaking. Although the topology of HCN resembles K(v) channels, much less is known about their structure-function correlation. Previously, we identified...

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Detalles Bibliográficos
Autores principales:	Siu, Chung Wah, Azene, Ezana M., Au, Ka Wing, Lau, Chu Pak, Tse, Hung Fat, Li, Ronald A.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718208/ https://www.ncbi.nlm.nih.gov/pubmed/19609824 http://dx.doi.org/10.1007/s00232-009-9184-2

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