Nonlinear pharmacokinetics of therapeutic proteins resulting from receptor mediated endocytosis

Receptor mediated endocytosis (RME) plays a major role in the disposition of therapeutic protein drugs in the body. It is suspected to be a major source of nonlinear pharmacokinetic behavior observed in clinical pharmacokinetic data. So far, mostly empirical or semi-mechanistic approaches have been...

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Detalles Bibliográficos
Autores principales: Krippendorff, Ben-Fillippo, Kuester, Katharina, Kloft, Charlotte, Huisinga, Wilhelm
Formato: Texto
Lenguaje:English
Publicado: Springer US 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718226/
https://www.ncbi.nlm.nih.gov/pubmed/19554432
http://dx.doi.org/10.1007/s10928-009-9120-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718226/
https://www.ncbi.nlm.nih.gov/pubmed/19554432
http://dx.doi.org/10.1007/s10928-009-9120-1

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