Two HIV-1 Variants Resistant to Small Molecule CCR5 Inhibitors Differ in How They Use CCR5 for Entry

HIV-1 variants resistant to small molecule CCR5 inhibitors recognize the inhibitor-CCR5 complex, while also interacting with free CCR5. The most common genetic route to resistance involves sequence changes in the gp120 V3 region, a pathway followed when the primary isolate CC1/85 was cultured with t...

Descripción completa

Detalles Bibliográficos
Autores principales: Berro, Reem, Sanders, Rogier W., Lu, Min, Klasse, Per J., Moore, John P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718843/
https://www.ncbi.nlm.nih.gov/pubmed/19680536
http://dx.doi.org/10.1371/journal.ppat.1000548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718843/
https://www.ncbi.nlm.nih.gov/pubmed/19680536
http://dx.doi.org/10.1371/journal.ppat.1000548

Ejemplares similares