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Two HIV-1 Variants Resistant to Small Molecule CCR5 Inhibitors Differ in How They Use CCR5 for Entry

HIV-1 variants resistant to small molecule CCR5 inhibitors recognize the inhibitor-CCR5 complex, while also interacting with free CCR5. The most common genetic route to resistance involves sequence changes in the gp120 V3 region, a pathway followed when the primary isolate CC1/85 was cultured with t...

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Detalles Bibliográficos
Autores principales:	Berro, Reem, Sanders, Rogier W., Lu, Min, Klasse, Per J., Moore, John P.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718843/ https://www.ncbi.nlm.nih.gov/pubmed/19680536 http://dx.doi.org/10.1371/journal.ppat.1000548

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