RNA Gain-of-Function in Spinocerebellar Ataxia Type 8

Microsatellite expansions cause a number of dominantly-inherited neurological diseases. Expansions in coding-regions cause protein gain-of-function effects, while non-coding expansions produce toxic RNAs that alter RNA splicing activities of MBNL and CELF proteins. Bi-directional expression of the s...

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Detalles Bibliográficos
Autores principales: Daughters, Randy S., Tuttle, Daniel L., Gao, Wangcai, Ikeda, Yoshio, Moseley, Melinda L., Ebner, Timothy J., Swanson, Maurice S., Ranum, Laura P. W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719092/
https://www.ncbi.nlm.nih.gov/pubmed/19680539
http://dx.doi.org/10.1371/journal.pgen.1000600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719092/
https://www.ncbi.nlm.nih.gov/pubmed/19680539
http://dx.doi.org/10.1371/journal.pgen.1000600

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