The Butyrylcholinesterase K Variant Confers Structurally Derived Risks for Alzheimer Pathology(♦)

The K variant of butyrylcholinesterase (BChE-K, 20% incidence) is a long debated risk factor for Alzheimer disease (AD). The A539T substitution in BChE-K is located at the C terminus, which is essential both for BChE tetramerization and for its capacity to attenuate β-amyloid (Aβ) fibril formation....

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Detalles Bibliográficos
Autores principales: Podoly, Erez, Shalev, Deborah E., Shenhar-Tsarfaty, Shani, Bennett, Estelle R., Ben Assayag, Einor, Wilgus, Harvey, Livnah, Oded, Soreq, Hermona
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Genomics, Proteomics, and Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719355/
https://www.ncbi.nlm.nih.gov/pubmed/19383604
http://dx.doi.org/10.1074/jbc.M109.004952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719355/
https://www.ncbi.nlm.nih.gov/pubmed/19383604
http://dx.doi.org/10.1074/jbc.M109.004952

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