Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas

BACKGROUND: DNA repair genes critically regulate the cellular response to chemotherapy and epigenetic regulation of these genes may be influenced by chemotherapy exposure. Restoration of BRCA1 and BRCA2 mediates resistance to platinum chemotherapy in recurrent BRCA1 and BRCA2 mutated hereditary ovar...

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Detalles Bibliográficos
Autores principales: Swisher, Elizabeth M, Gonzalez, Rachel M, Taniguchi, Toshiyasu, Garcia, Rochelle L, Walsh, Tom, Goff, Barbara A, Welcsh, Piri
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719582/
https://www.ncbi.nlm.nih.gov/pubmed/19602291
http://dx.doi.org/10.1186/1476-4598-8-48

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719582/
https://www.ncbi.nlm.nih.gov/pubmed/19602291
http://dx.doi.org/10.1186/1476-4598-8-48

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