Efficient, chemoselective synthesis of immunomicelles using single-domain antibodies with a C-terminal thioester

BACKGROUND: Classical bioconjugation strategies for generating antibody-functionalized nanoparticles are non-specific and typically result in heterogeneous compounds that can be compromised in activity. Expression systems based on self-cleavable intein domains allow the generation of recombinant pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Reulen, Sanne WA, van Baal, Ingrid, Raats, Jos MH, Merkx, Maarten
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719619/
https://www.ncbi.nlm.nih.gov/pubmed/19619333
http://dx.doi.org/10.1186/1472-6750-9-66

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719619/
https://www.ncbi.nlm.nih.gov/pubmed/19619333
http://dx.doi.org/10.1186/1472-6750-9-66

Ejemplares similares