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Efficient, chemoselective synthesis of immunomicelles using single-domain antibodies with a C-terminal thioester
BACKGROUND: Classical bioconjugation strategies for generating antibody-functionalized nanoparticles are non-specific and typically result in heterogeneous compounds that can be compromised in activity. Expression systems based on self-cleavable intein domains allow the generation of recombinant pro...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719619/ https://www.ncbi.nlm.nih.gov/pubmed/19619333 http://dx.doi.org/10.1186/1472-6750-9-66 |