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The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle

Glycolipids are presented to T cells by human group 1 CD1 proteins, but are not used as subunit vaccines yet. Experimental immunizations with pure mycobacterial glucose monomycolate (GMM) and keyhole limpet haemocyanin (KLH) in cattle, a species which, unlike mice, expresses group 1 CD1, showed that...

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Detalles Bibliográficos
Autores principales: Nguyen, Thi Kim Anh, Koets, Ad P., Santema, Wiebren J., van Eden, Willem, Rutten, Victor P.M.G., Van Rhijn, Ildiko
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719691/
https://www.ncbi.nlm.nih.gov/pubmed/19538998
http://dx.doi.org/10.1016/j.vaccine.2009.05.078
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author Nguyen, Thi Kim Anh
Koets, Ad P.
Santema, Wiebren J.
van Eden, Willem
Rutten, Victor P.M.G.
Van Rhijn, Ildiko
author_facet Nguyen, Thi Kim Anh
Koets, Ad P.
Santema, Wiebren J.
van Eden, Willem
Rutten, Victor P.M.G.
Van Rhijn, Ildiko
author_sort Nguyen, Thi Kim Anh
collection PubMed
description Glycolipids are presented to T cells by human group 1 CD1 proteins, but are not used as subunit vaccines yet. Experimental immunizations with pure mycobacterial glucose monomycolate (GMM) and keyhole limpet haemocyanin (KLH) in cattle, a species which, unlike mice, expresses group 1 CD1, showed that GMM was equally efficient as KLH in generating T cell responses in blood, but not in the draining lymph node. Also, KLH induced strong antibody responses whereas GMM did not. These data suggest that non-overlapping T cell populations are targeted and demonstrate the potential of glycolipids as a special class of subunit vaccine candidates.
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spelling pubmed-27196912009-08-18 The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle Nguyen, Thi Kim Anh Koets, Ad P. Santema, Wiebren J. van Eden, Willem Rutten, Victor P.M.G. Van Rhijn, Ildiko Vaccine Article Glycolipids are presented to T cells by human group 1 CD1 proteins, but are not used as subunit vaccines yet. Experimental immunizations with pure mycobacterial glucose monomycolate (GMM) and keyhole limpet haemocyanin (KLH) in cattle, a species which, unlike mice, expresses group 1 CD1, showed that GMM was equally efficient as KLH in generating T cell responses in blood, but not in the draining lymph node. Also, KLH induced strong antibody responses whereas GMM did not. These data suggest that non-overlapping T cell populations are targeted and demonstrate the potential of glycolipids as a special class of subunit vaccine candidates. Elsevier Science 2009-07-30 /pmc/articles/PMC2719691/ /pubmed/19538998 http://dx.doi.org/10.1016/j.vaccine.2009.05.078 Text en © 2009 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Nguyen, Thi Kim Anh
Koets, Ad P.
Santema, Wiebren J.
van Eden, Willem
Rutten, Victor P.M.G.
Van Rhijn, Ildiko
The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle
title The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle
title_full The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle
title_fullStr The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle
title_full_unstemmed The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle
title_short The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle
title_sort mycobacterial glycolipid glucose monomycolate induces a memory t cell response comparable to a model protein antigen and no b cell response upon experimental vaccination of cattle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719691/
https://www.ncbi.nlm.nih.gov/pubmed/19538998
http://dx.doi.org/10.1016/j.vaccine.2009.05.078
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