Cargando…

Structures of native human thymidine phosphorylase and in complex with 5-iodouracil

Thymidine phosphorylase (TP) first identified as platelet derived endothelial cell growth factor (PD-ECGF) plays a key role in nucleoside metabolism. Human TP (hTP) is implicated in angiogenesis and is overexpressed in several solid tumors. Here, we report the crystal structures of recombinant hTP a...

Descripción completa

Detalles Bibliográficos
Autores principales: Mitsiki, Eirini, Papageorgiou, Anastassios C., Iyer, Shalini, Thiyagarajan, Nethaji, Prior, Steven H., Sleep, Darrell, Finnis, Chris, Acharya, K. Ravi
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719695/
https://www.ncbi.nlm.nih.gov/pubmed/19555658
http://dx.doi.org/10.1016/j.bbrc.2009.06.104