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Structures of native human thymidine phosphorylase and in complex with 5-iodouracil

Thymidine phosphorylase (TP) first identified as platelet derived endothelial cell growth factor (PD-ECGF) plays a key role in nucleoside metabolism. Human TP (hTP) is implicated in angiogenesis and is overexpressed in several solid tumors. Here, we report the crystal structures of recombinant hTP a...

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Detalles Bibliográficos
Autores principales:	Mitsiki, Eirini, Papageorgiou, Anastassios C., Iyer, Shalini, Thiyagarajan, Nethaji, Prior, Steven H., Sleep, Darrell, Finnis, Chris, Acharya, K. Ravi
Formato:	Texto
Lenguaje:	English
Publicado:	Academic Press 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719695/ https://www.ncbi.nlm.nih.gov/pubmed/19555658 http://dx.doi.org/10.1016/j.bbrc.2009.06.104

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