Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

Many cancer cells display a CIN (Chromosome Instability) phenotype, by which they exhibit high rates of chromosome loss or gain at each cell cycle. Over the years, a number of different mechanisms, including mitotic spindle multipolarity, cytokinesis failure, and merotelic kinetochore orientation, h...

Descripción completa

Detalles Bibliográficos
Autores principales: Silkworth, William T., Nardi, Isaac K., Scholl, Lindsey M., Cimini, Daniela
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719800/
https://www.ncbi.nlm.nih.gov/pubmed/19668340
http://dx.doi.org/10.1371/journal.pone.0006564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719800/
https://www.ncbi.nlm.nih.gov/pubmed/19668340
http://dx.doi.org/10.1371/journal.pone.0006564

Ejemplares similares