Cargando…

Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia

BACKGROUND: The essential aetiology of radiation-induced acute myeloid leukaemia (AML) in mice is the downregulation of the transcription factor PU.1. The causative mutation of the PU.1-endocing Sfpi1 gene consists mostly of C:G to T:A transitions at a CpG site and is likely to be of spontaneous ori...

Descripción completa

Detalles Bibliográficos
Autores principales: Ban, N, Kai, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720201/
https://www.ncbi.nlm.nih.gov/pubmed/19513063
http://dx.doi.org/10.1038/sj.bjc.6605135