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Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia
BACKGROUND: The essential aetiology of radiation-induced acute myeloid leukaemia (AML) in mice is the downregulation of the transcription factor PU.1. The causative mutation of the PU.1-endocing Sfpi1 gene consists mostly of C:G to T:A transitions at a CpG site and is likely to be of spontaneous ori...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720201/ https://www.ncbi.nlm.nih.gov/pubmed/19513063 http://dx.doi.org/10.1038/sj.bjc.6605135 |