The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models

BACKGROUND: We investigated, in the panel of 60 human tumour cell lines of the National Cancer Institute (NCI-60), whether the R72P polymorphism of TP53 and the T309G polymorphism of MDM2 were associated to the in vitro cytotoxicity of anticancer agents, extracted from the NCI database. For validati...

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Detalles Bibliográficos
Autores principales: Faur, N, Araud, L, Laroche-Clary, A, Kanno, J, Toutain, J, Yamori, T, Robert, J, Le Morvan, V
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720206/
https://www.ncbi.nlm.nih.gov/pubmed/19513075
http://dx.doi.org/10.1038/sj.bjc.6605096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720206/
https://www.ncbi.nlm.nih.gov/pubmed/19513075
http://dx.doi.org/10.1038/sj.bjc.6605096

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