Cargando…

The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models

BACKGROUND: We investigated, in the panel of 60 human tumour cell lines of the National Cancer Institute (NCI-60), whether the R72P polymorphism of TP53 and the T309G polymorphism of MDM2 were associated to the in vitro cytotoxicity of anticancer agents, extracted from the NCI database. For validati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Faur, N, Araud, L, Laroche-Clary, A, Kanno, J, Toutain, J, Yamori, T, Robert, J, Le Morvan, V
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720206/ https://www.ncbi.nlm.nih.gov/pubmed/19513075 http://dx.doi.org/10.1038/sj.bjc.6605096

Ejemplares similares

The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
por: Sinilnikova, O M, et al.
Publicado: (2009)

Prognostic potential of the MDM2 309T>G polymorphism in stage I lung adenocarcinoma
por: Enokida, Yasuaki, et al.
Publicado: (2016)

The MDM2 Single-Nucleotide Polymorphism T309G Is Associated With the Development of Epimacular Membranes
por: Jiang, Heng, et al.
Publicado: (2022)

Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma
por: Hori, Yasuki, et al.
Publicado: (2015)

Have the roles of two functional polymorphisms in breast cancer, R72P in P53 and MDM2-309 in MDM2, become clearer?
por: Scott, Rodney J
Publicado: (2010)

The T309G MDM2 Gene Polymorphism Is a Novel Risk Factor for Proliferative Vitreoretinopathy
por: Pastor-Idoate, Salvador, et al.
Publicado: (2013)

MDM2 SNP309 polymorphism is associated with colorectal cancer risk
por: Wang, Weizhi, et al.
Publicado: (2014)

MDM2 SNP309 promoter polymorphism and p53 mutations in urinary bladder carcinoma stage T1
por: Olsson, Hans, et al.
Publicado: (2013)

Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer
por: YONEDA, TOMOKO, et al.
Publicado: (2013)

Correction: Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma
Publicado: (2015)

Significant Association of the MDM2 T309G Polymorphism with Breast Cancer Risk in a Turkish Population
por: Yilmaz, Meral, et al.
Publicado: (2018)

Single-Nucleotide Polymorphism 309T>G in the MDM2 Promoter Determines Functional Outcome After Stroke
por: Rodríguez, Cristina, et al.
Publicado: (2018)

Correlations between MDM2 gene SNP309 Polymorphism and Susceptibility to Leukemia
por: Ou, Wen-Bin
Publicado: (2015)

The frequency of TP53 R72P and MDM2 309T>G polymorphisms in Iranian infertile men with spermatogenetic failure: A case-control study
por: Ebrahim Abadi, Zeinab, et al.
Publicado: (2018)

The MDM2 309T>G Polymorphism and Ovarian Cancer Risk: A Meta-Analysis of 1534 Cases and 2211 Controls
por: Ma, Ying-Yu, et al.
Publicado: (2013)

Correlation between MDM2 T309G single nucleotide polymorphism and esophageal cancer susceptibility: An updated meta‐analysis
por: Yin, Lele, et al.
Publicado: (2020)

Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients
por: Schmidt, Marjanka K, et al.
Publicado: (2009)

An Updated Meta-Analysis on the Association of MDM2 SNP309 Polymorphism with Colorectal Cancer Risk
por: Qin, Xue, et al.
Publicado: (2013)

Cirrhotic livers reveal genetic changes in the MDM2-P14ARF system of cell cycle regulators
por: Schlott, T, et al.
Publicado: (2002)

Relationship Between Murine Double Minute 2 (MDM2) T309G Polymorphism and Endometrial Cancer Risk: A Meta-Analysis
por: Xue, Zhuowei, et al.
Publicado: (2016)

Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma
por: Schernhammer, E S, et al.
Publicado: (2006)

MDM2 SNP309 rs2279744 Polymorphism and Gastric Cancer Risk: A Meta-Analysis
por: Ma, Yong, et al.
Publicado: (2013)

Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers
por: Bjørnslett, Merete, et al.
Publicado: (2012)

Rapid Detection of SNP (c.309T>G) in the MDM2 Gene by the Duplex SmartAmp Method
por: Enokida, Yasuaki, et al.
Publicado: (2013)

Prognostic Impact of the MDM2(SNP309) Allele in Leukemia and Lymphoma
por: Post, Sean M., et al.
Publicado: (2010)

A case‐control study on the SNP309T → G and 40‐bp Del1518 of the MDM2 gene and a systematic review for MDM2 polymorphisms in the patients with breast cancer
por: Jalilvand, Amin, et al.
Publicado: (2020)

MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism
por: Paulin, Fiona EM, et al.
Publicado: (2008)

The association of polymorphic markers Arg399Gln of XRCC1 gene, Arg72Pro of TP53 gene and T309G of MDM2 gene with breast cancer in Kyrgyz females
por: Isakova, Jainagul, et al.
Publicado: (2017)

Mdm2-SNP309 polymorphism in prostate cancer: no evidence for association with increased risk or histopathological tumour characteristics
por: Stoehr, R, et al.
Publicado: (2008)

Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers
por: Copson, Ellen R, et al.
Publicado: (2006)

MDM2 SNP309 polymorphism contributes to endometrial cancer susceptibility: evidence from a meta-analysis
por: Peng, Qiliu, et al.
Publicado: (2013)

Effect of MDM2 SNP309 and p53 codon 72 polymorphisms on lung cancer risk and survival among non-smoking Chinese women in Singapore
por: Chua, Hui Wan, et al.
Publicado: (2010)

ODP281 JDP2 Interacts with MDM2 and Decreases MDM2-Mediated p53 Repression
por: Yang, William, et al.
Publicado: (2022)

An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BRCA1 and BRCA2 mutation carriers
por: Osorio, A, et al.
Publicado: (2008)

Association between MDM2 SNP309 T>G polymorphism and the risk of bladder cancer: new data in a Chinese population and an updated meta-analysis
por: Xie, Linguo, et al.
Publicado: (2015)

Effects of the single nucleotide polymorphism at MDM2 309 on breast cancer patients with/without BRCA1/2 mutations
por: Nechushtan, Hovav, et al.
Publicado: (2009)

MDM2 SNP309 polymorphism is associated with lung cancer risk in women: A meta-analysis using METAGEN
por: HE, WENWU, et al.
Publicado: (2012)

Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy
por: Zhou, Guohong, et al.
Publicado: (2017)

Effects of G/A polymorphism, rs266882, in the androgen response element 1 of the PSA gene on prostate cancer risk, survival and circulating PSA levels
por: Jesser, C, et al.
Publicado: (2008)

The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma
por: Linnebank, M, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_k46hvj9in2889cgu2rg5je2st0