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Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although chromosomal histones are stable, excess (non-chromatin bou...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720428/ https://www.ncbi.nlm.nih.gov/pubmed/19578373 http://dx.doi.org/10.1038/ncb1903 |