Loss of the Putative Catalytic Domain of HDAC4 Leads to Reduced Thermal Nociception and Seizures while Allowing Normal Bone Development

Histone deacetylase 4 (HDAC4) has been associated with muscle & bone development [1]–[6]. N-terminal MEF2 and RUNX2 binding domains of HDAC4 have been shown to mediate these effects in vitro. A complete gene knockout has been reported to result in premature ossification and associated defects re...

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Detalles Bibliográficos
Autores principales: Rajan, Indrani, Savelieva, Katerina V., Ye, Gui-Lan, Wang, Ching-yun, Malbari, Murtaza M., Friddle, Carl, Lanthorn, Thomas H., Zhang, Wandong
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720538/
https://www.ncbi.nlm.nih.gov/pubmed/19672313
http://dx.doi.org/10.1371/journal.pone.0006612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720538/
https://www.ncbi.nlm.nih.gov/pubmed/19672313
http://dx.doi.org/10.1371/journal.pone.0006612

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