Differential Sensitivity and Mechanism of Inhibition of COX-2 Oxygenation of Arachidonic Acid and 2-Arachidonoylglycerol by Ibuprofen and Mefenamic Acid

[Image: see text] Ibuprofen and mefenamic acid are weak, competitive inhibitors of cyclooxygenase-2 (COX-2) oxygenation of arachidonic acid (AA) but potent, noncompetitive inhibitors of 2-arachidonoylglycerol (2-AG) oxygenation. The slow, tight-binding inhibitor, indomethacin, is a potent inhibitor...

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Detalles Bibliográficos
Autores principales: Prusakiewicz, Jeffery J., Duggan, Kelsey C., Rouzer, Carol A., Marnett, Lawrence J.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720641/
https://www.ncbi.nlm.nih.gov/pubmed/19603831
http://dx.doi.org/10.1021/bi900999z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720641/
https://www.ncbi.nlm.nih.gov/pubmed/19603831
http://dx.doi.org/10.1021/bi900999z

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