Epigenetic Engineering of Ribosomal RNA Genes Enhances Protein Production

Selection of mammalian high-producer cell lines remains a major challenge for the biopharmaceutical manufacturing industry. Ribosomal RNA (rRNA) genes encode the major component of the ribosome but many rRNA gene copies are not transcribed [1]–[5] due to epigenetic silencing by the nucleolar remodel...

Descripción completa

Detalles Bibliográficos
Autores principales: Santoro, Raffaella, Lienemann, Philipp, Fussenegger, Martin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721416/
https://www.ncbi.nlm.nih.gov/pubmed/19680546
http://dx.doi.org/10.1371/journal.pone.0006653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721416/
https://www.ncbi.nlm.nih.gov/pubmed/19680546
http://dx.doi.org/10.1371/journal.pone.0006653

Ejemplares similares