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Epigenetic Engineering of Ribosomal RNA Genes Enhances Protein Production
Selection of mammalian high-producer cell lines remains a major challenge for the biopharmaceutical manufacturing industry. Ribosomal RNA (rRNA) genes encode the major component of the ribosome but many rRNA gene copies are not transcribed [1]–[5] due to epigenetic silencing by the nucleolar remodel...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721416/ https://www.ncbi.nlm.nih.gov/pubmed/19680546 http://dx.doi.org/10.1371/journal.pone.0006653 |