Timed Somatic Deletion of p53 in Mice Reveals Age-Associated Differences in Tumor Progression

Inactivating mutations in the p53 tumor suppressor gene occur often in the progression of human cancers. p53 inhibits the outgrowth of nascent cancer cells through anti-proliferative actions (including induction of apoptosis or senescence). To test p53 tumor suppressor functions in a novel experimen...

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Detalles Bibliográficos
Autores principales: Hinkal, George, Parikh, Neha, Donehower, Lawrence A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721630/
https://www.ncbi.nlm.nih.gov/pubmed/19680549
http://dx.doi.org/10.1371/journal.pone.0006654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721630/
https://www.ncbi.nlm.nih.gov/pubmed/19680549
http://dx.doi.org/10.1371/journal.pone.0006654

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