CK2 Is the Regulator of SIRT1 Substrate-Binding Affinity, Deacetylase Activity and Cellular Response to DNA-Damage

SIRT1, an NAD(+) (nicotinamide adenine dinucleotide)-dependent deacetylase, protects cells from stress-induced apoptosis, and its orthologues delay aging in lower eukaryotes. SIRT1 increases survival in response to stress such as DNA damage by deacetylating a number of substrates including pro-apopt...

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Detalles Bibliográficos
Autores principales: Kang, Hyeog, Jung, Jae-Won, Kim, Myung K., Chung, Jay H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721681/
https://www.ncbi.nlm.nih.gov/pubmed/19680552
http://dx.doi.org/10.1371/journal.pone.0006611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721681/
https://www.ncbi.nlm.nih.gov/pubmed/19680552
http://dx.doi.org/10.1371/journal.pone.0006611

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