A Novel Two-Step Hierarchical Quantitative Structure–Activity Relationship Modeling Work Flow for Predicting Acute Toxicity of Chemicals in Rodents

BACKGROUND: Accurate prediction of in vivo toxicity from in vitro testing is a challenging problem. Large public–private consortia have been formed with the goal of improving chemical safety assessment by the means of high-throughput screening. OBJECTIVE: A wealth of available biological data requir...

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Detalles Bibliográficos
Autores principales: Zhu, Hao, Ye, Lin, Richard, Ann, Golbraikh, Alexander, Wright, Fred A., Rusyn, Ivan, Tropsha, Alexander
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721870/
https://www.ncbi.nlm.nih.gov/pubmed/19672406
http://dx.doi.org/10.1289/ehp.0800471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721870/
https://www.ncbi.nlm.nih.gov/pubmed/19672406
http://dx.doi.org/10.1289/ehp.0800471

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